We Review Supplements for a Living—These 6 Will Be Big in 2025

If you’re curious about what’s trending in the supplement world this year (and actually trustworthy), consider this your guide. As registered dietitians and Health nutrition editors, we spend most of the year digging through the latest research and trends, always looking for the best new supplements hitting the market. Now that it’s 2025, it’s the perfect time to evaluate which ones will be worth trying in the next 12 months and beyond. 

There are different reasons supplements reach trend status. While some have been popular for a while (hello, magnesium), emerging research pointing to new benefits or new formats (AKA liquid, gummy, or tablet) that make them easier to take will push them to greater heights. Others, like lion’s mane, have been used for centuries but are starting to gain headway as supplements. You might not have heard of one or two of these, like NAD, but we guarantee you’ll start to see them popping up all over in 2025. 

After reviewing countless supplements, we think these ones will take off and may be worth investing in.

Dietary supplements are minimally regulated by the FDA and may or may not be suitable for you. Please always speak with a healthcare provider to discuss any supplements you plan on taking.

Mushrooms have been used in traditional Chinese medicine for centuries to treat various health issues. These days, mushroom supplements are gaining in popularity because of their wide range of potential health benefits, including improved cognitive function like memory and focus—which is why you’ll see them in protein powders, coffee alternatives, bars, multivitamins, and more.  Lion’s mane, in particular, contains compounds that may also improve overall mood, including anxiety and depression. However, while promising, most studies on the subject are limited in scale, and more research is needed. 

Lion’s mane contains compounds that may have anti-inflammatory, anti-microbial, and anti-cancer properties. It’s generally considered safe with few side effects and is found mainly in capsule form like this option from Real Mushrooms. You can also find it as a powder like Om Lion’s Mane, which can easily be added to smoothies or coffee. Keep in mind there are many types of mushrooms, and we’re talking about edible and culinary mushrooms—not the psychedelic kind!

Protein powders aren’t a new trend per se, but the buzz will continue in 2025 (and beyond) thanks to the focus on protein, especially regarding weight loss. One new protein powder trend is clear whey protein, like MyProtein Clear Whey Isolate. Clear whey is meant to taste more like juice—a light, refreshing change for some—instead of a traditional thick, milky protein shake. The clear whey is fruit-flavored instead of traditional vanilla or chocolate, is sugar-free, and is low in calories.

In addition to clear protein powder, companies are adding unique ingredients to protein powder, including extra vitamins, minerals, adaptogens, colostrum, creatine, and more. This ingredient additions means you can get even more oomph out of your protein powder.

According to the World Health Organization (WHO), by 2030, one in six people globally will be over age 60. As the population gets older, anti-aging supplements will continue to come to the forefront. Supplements like collagen and turmeric are standard anti-aging supplements, but a new anti-aging supplement called nicotinamide adenine dinucleotide (NAD) is gaining popularity. 

NAD, a naturally occurring coenzyme, is involved in cell metabolism and energy production. Unfortunately, NAD levels decrease as we age. However, supplementing with NAD as we age may help boost energy levels and protect against chronic diseases due to its anti-inflammatory properties.

Note that NAD supplements contain the precursor nicotinamide riboside (NR), which provides body cells with the building blocks of NAD. Some studies suggest that NR supplements, like Tru Niagen, can help raise NAD levels in the body. We like Tru Niagen because it uses a patented form of NR, is independently verified, and has research studies supporting its benefits.

NAD supplement with added antioxidants

Berberine, a natural plant compound, is gaining popularity for its potential health benefits. In studies, it’s shown to help regulate blood glucose, lower high cholesterol levels, and possibly reduce inflammation. It may help improve insulin resistance by helping the liver produce less insulin and fat, working similarly to the prescription glucose-lowering drug metformin.

With the rise in popularity of GLP-1 drugs like Ozempic for diabetes and weight loss, berberine has earned the nickname “nature’s Ozempic” on social media due to its reported weight loss benefits, which research has found to be modest. Some studies also suggest that berberine can help promote and stimulate GLP production. However, it is not as effective or considered a replacement for GLP-1 medications but may help slightly with weight management. 

Berberine is well-tolerated, with mild side effects, including stomach upset. Because of this and its potential health benefits, we expect it to continue to trend in 2025. It is widely available in capsule form, like this one from Enzymedica.

Pre- and probiotics seem to be everywhere and in everything. While they aren’t new, ongoing research is helping to expand probiotic supplement options. We are excited about a new probiotic trend in 2025: probiotics specifically formulated to target specific issues beyond gut health, like weight management, oral and mental health, and women’s health. For example, Pendulum’s Akkermansia probiotic contains Akkermansia muciniphilia, a strain research suggests can improve insulin sensitivity, reduce inflammation, and potentially help with weight management.

Another example is a probiotic from Enzymedica’s new SubCulture™ Probiotics line, designed to improve mood, sleep, and stress. Along with a probiotic blend, it features a postbiotic strain, Lactobacillus gasseri CP2305, which research has linked to better mental well-being, sleep, and improved gut bacteria. It also incorporates L-theanine, an amino acid that supports cognitive function and reduces stress.

Additionally, the dental probiotic BioGaia Prodentis contains the research-backed strain Lactobacillus reuteri. This specific strain can help reduce the risk of cavities, gingivitis, and bad breath by improving the balance of bacteria in the mouth. 

Custom probiotics, like Flore, are gaining popularity. These individually-customized supplements are created based on an at-home microflora test. A kit is mailed to you, you send back a stool sample, and they create custom probiotics from more than 115 pre and pro-biotic strains based on your microbiome.

Like vitamin D, magnesium is a nutrient most people don’t get enough of through food alone. Because of this, magnesium supplements are increasingly popular, and different types of magnesium are coming to the forefront, like magnesium L-threonate. Some research suggests Magtein—a specific form of magnesium L-threonate—may help improve memory and brain function in adults because it can cross the blood-brain barrier to reach brain and neuron cells. If you’re looking for a boost in magnesium with this potential brain health benefit, we like Life Extension Neuro-Mag because it uses the researched Magtein form, and each three-capsule serving provides 34% Daily Value for magnesium.

Liposomal magnesium threonate in vanilla cream pouches

Another quality magnesium L-threonate 3 capsule supplement