Close Menu
    Trending
    Login
    Local

    Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products

    Savannah HeraldBy 2 Mins Read
    Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products

    Scientific research & Discovery: Discover the World Via Study and Technology

    Key takeaways
    • The site-directed nuclease (SDN) classification fails as a regulatory trigger; edit outcomes, not editing method, determine biological risk.
    • Emerging tools like base editing and prime editing blur SDN1, SDN2, and SDN3 distinctions, complicating regulatory categorization.
    • Advocate for product-based regulation focused on trait-level risk assessment and science-based, proportionate oversight.
    • Current classifications hinder trade and enforcement because small edits can be indistinguishable from natural variation.
    • Harmonization across jurisdictions with transparent, evidence-based criteria will enable innovation while preserving environmental and food safety.

  • Slewinski, T. L., Turner-Hissong, S., Paciorek, T., Brower-Toland, B. & & Shyu, C. Plant Physiol. 199 , kiaf 378 (2025

    Post
    PubMed
    PubMed Central
    CAS
    Google Scholar

  • Voss-Fels, K. P., Stahl, A. & & Hickey, L. T. Q. BMC Biol. 17 , 18 (2019

    Write-up
    PubMed
    PubMed Central
    Google Scholar

  • Podevin, N., Davies, H. V., Hartung, F., Nogué, F. & & Casacuberta, J. M. Trends Biotechnol. 31 , 375– 383 (2013

    Short article
    PubMed
    CAS
    Google Scholar

  • Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & & Liu, D. R. Nature 533 , 420– 424 (2016

    Article
    PubMed
    PubMed Central
    CAS
    Google Scholar

  • Anzalone, A. V. et al. Nature 576 , 149– 157(2019

    Article PubMed PubMed Central CAS Google Scholar

  • Papikian, A., Liu, W., Gallego-Bartolomé, J. & Jacobsen, S. E. Nat. Commun. 10 , 729(2019

    Short article PubMed PubMed Central CAS Google Scholar

  • Thiebaut, F., Hemerly, A. S. & Ferreira, P. C. G. Front. Plant Sci. 10 , 246(2019

    Article PubMed PubMed Central Google Scholar

  • Kakoulidou, I. et al. Biology( Basel) 10 , 766(2021

    PubMed PubMed Central CAS Google Scholar

  • Mercé, C., Bayer, P. E., Tay Fernandez, C., Batley, J. & Edwards, D. Agronomy (Basel) 10 , 1484(2020

    [**********************************************************************
    ] Short article Google Scholar

  • Lynagh, P. G. et al. Preprint at bioRxiv https://doi.org/ 10 1101/ 400507 (2018

  • Gehrke, F., Schindele, A. & Puchta, H. Plant Physiol. 188 , 1769– 1779(2022

    Write-up PubMed PubMed Central CAS
     Google Scholar

  • Zhao, Y. et al. Nat. Plants 11 , 2461– 2475(2025

    [************************************************************************************
    ] Post PubMed CAS Google Scholar

  • Schwartz, C. et al. Nat. Plants 6 , 1427– 1431(2020

    Article PubMed CAS Google Scholar

  • Sun, C. et al. Nat. Biotechnol. 42 , 316– 327(2024

    Write-up PubMed CAS
     Google Scholar

  • Lyzenga, W. J., Pozniak, C. J. & Kagale, S. Plant Biotechnol. J. 19 , 660– 670(2021

    Write-up PubMed PubMed Central CAS
     Google Scholar

  • Taagen, E., Bogdanove, A. J. & Sorrells, M. E. Patterns Plant Sci. 25 , 455– 465(2020

    Short article PubMed CAS
     Google Scholar

  • Jenkins, D., Juba, N., Crawford, B., Worthington, M. & Hummel, A. Nat. Plants 9 , 679– 684(2023

    Post PubMed Google Scholar

  • Plant reproducing development: regular criteria for the scope of regulative oversight. International Seed Federation https://worldseed.org/wp-content/uploads/ 2018/ 06/ Plant-breeding-innovation-Consistent-criteria-for-the-scope-of-regulatory-oversight. pdf (2018


    • Read the complete post from the initial source

    Share.

    Related Posts

    Comments are closed.